- Original Article
- Cardiology
- Changes of Bax, Bcl-2, CCR-2, MCP-1, and TGF-β1 genes in the left ventricle of spontaneously hypertensive rat after losartan treatment
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Hyeryon Lee, Kwan Chang Kim, Young Mi Hong
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Clin Exp Pediatr. 2019;62(3):95-101. Published online October 24, 2018
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Purpose: Increased apoptosis was recently found in the hypertrophied left ventricle of spontaneously hypertensive rats (SHRs). Although the available evidence suggests that apoptosis can be induced in cardiac cells by various insults including pressure overload, cardiac apoptosis appears to result from an exaggerated local production of angiotensin in adult SHRs. Altered expressions of Bcl associated X (Bax), Bcl-2, chemokine receptor... |
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- Change of voltage-gated potassium channel 1.7 expressions in monocrotaline-induced pulmonary arterial hypertension rat model
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Hyeryon Lee, Kwan Chang Kim, Young Mi Hong
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Clin Exp Pediatr. 2018;61(9):271-278. Published online September 15, 2018
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Purpose: Abnormal potassium channels expression affects vessel function, including vascular tone and proliferation rate. Diverse potassium channels, including voltage-gated potassium (Kv) channels, are involved in pathological changes of pulmonary arterial hypertension (PAH). Since the role of the Kv1.7 channel in PAH has not been previously studied, we investigated whether Kv1.7 channel expression changes in the lung tissue of a monocrotaline... |
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- Apoptosis and remodeling in adriamycin-induced cardiomyopathy rat model
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Young Mi Hong, Hyeryon Lee, Min-Sun Cho, Kwan Chang Kim
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Clin Exp Pediatr. 2017;60(11):365-372. Published online November 27, 2017
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Purpose The mechanism for the pathogenesis of adriamycin (ADR)-induced cardiomyopathy is not yet known. Different hypotheses include the production of free radicals, an interaction between ADR and nuclear components, and a disruption in cardiac-specific gene expression. Apoptosis has also been proposed as being involved in cardiac dysfunction. The purpose of this study was to determine if apoptosis might play a role... |
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- The effect of sildenafil on right ventricular remodeling in a rat model of monocrotaline-induced right ventricular failure
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Hyun Kyung Bae, Hyeryon Lee, Kwan Chang Kim, Young Mi Hong
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Clin Exp Pediatr. 2016;59(6):262-270. Published online June 30, 2016
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Purpose Pulmonary arterial hypertension (PAH) leads to right ventricular failure (RVF) as well as an increase in pulmonary vascular resistance. Our purpose was to study the effect of sildenafil on right ventricular remodeling in a rat model of monocrotaline (MCT)-induced RVF. MethodsThe rats were distributed randomly into 3 groups. The control (C) group, the monocrotaline (M) group (MCT 60 mg/kg) and the... |
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